I stumbled on the blog Cosmic Variance which is about...well, I'm not quite sure what. I've read three posts and they were all pretty out there. The last was most interesting - it talks about a bunch of things, not least of them being whether it's more likely that we're the beings we think we are or that we're random fluctuations in the vacuum (or maybe the less-than vacuum).
Really, it's quite beyond summary and I recommend you check it out. Especially if you've been doing drugs...